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More accurate technique for understanding joint behaviour
"I hope our method will contribute to uncovering the secrets of osteoarthritis in the future" - Dr Kamel Madi.
Technique measures joint strain under conditions mimicking normal use

Scientists have discovered a new technique for understanding joint behaviour in conditions like osteoarthritis with more accuracy than ever before.

The groundbreaking technique, published in Nature Research, employs high-resolution imaging and specially-designed software code to gain a deeper understanding of how joints react as osteoarthritis progresses.

Joint strain is traditionally measured on the nanometer scale on tissue structures such as collagen fibres, chondrocyte cells and bones.

Until now, such strains have only been measured at the sub-millimetre scale in whole joints during loading. In this study, scientists measured these strains in mouse knee joints with an accuracy greater than 100 nanometers - 1,000 times more precise than before.

The study involved male ‘STR/Ort’ mice, which develop a natural form of osteoarthritis with age, similar to the human disease. The researchers then compared these mice with male age-matched control mice that did not display any signs of age-related osteoarthritis.  

It used combination of x-ray tomography, a nano-precision loading frame and a software code designed to measure motion between subsequent 3D images with a resolution of 1/20th of a voxel (3D pixel).

Researchers found that in young, older and arthritic mice, changes in tissue structure and mechanical behaviour can be simultaneously visualised, and that tissue structure at the cellular level is comparative with the mechanical performance of the joint as a whole.

The collaborative study was conducted by researchers from the Royal Veterinary College (RVC), Edinburgh Napier University, University College London, Oregon State University (US), 3Dmagination and the Diamond Light Source.

RVC skeletal dynamics professor Andrew A Pitsillides, explained: “Our technique for nanometre scale measurement of real deformation in whole joints under conditions closely mimicking their normal use will, I hope, bring new understanding of joint behaviour in health and in osteoarthritis that devastates the lives of so many.”

3Dmagination Ltd director Dr Kamel Madi, added: “Measuring precise and reliable nanoscale strains in this complex biomedical system requires a perfect blend of skills, from in situ imaging to reconstruction and quantification of several terabytes of dataset, which is the team’s expertise at 3Dmagination Ltd.

“I am also passionate about bringing the images to life and I hope our method will contribute to uncovering the secrets of osteoarthritis in the future.”

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Government to run free webinars on exporting horses

News Story 1
 The UK government has announced that it will be running two free webinars for horse owners and exporters, explaining what steps to take to export horses from 1 January 2021.

The first webinar will take place on Tuesday 20 October 2020, from 9.30am to 11am. It will cover Export Health Certificate (EHC) requirements from 1 January 2021. Click here to register.

The second webinar will take place on Wednesday 4 November 2020, from 10.30am to 12pm. This session will focus on the steps that businesses need to take to export equines from the UK to the EU. Click here to register.

For more information on exporting horses and ponies after 1 January 2021, please visit the gov.uk website. 

Click here for more...
News Shorts
More cases of African swine fever confirmed in Germany

More cases of African swine fever (ASF) have been confirmed in wild boar in Germany.

According to Pig World, 20 outbreaks have been identified in two districts - Brandenburg, where the original case confirmed on September 10 was found, and near the town of Neuzelle, some 7.5 km away.

The finding represents a further seven cases confirmed by Germany's Friedrich-Loeffler Institute. A Central Crisis Team has been established to coordinate the response to the outbreak.