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Nobel Prize awarded for enzyme research
Frances H. Arnold, George P. Smith and Sir Gregory Winter, 2018 Nobel Laureates in Chemistry.

Three scientists share 2018 Nobel Prize in Chemistry

The Nobel Prize in Chemistry 2018 has been awarded to three scientists for their research into enzymes.

Frances H. Arnold from the California Institute of Technology will share the award with George P. Smith, University of Missouri, and Sir Gregory P Winter from the MRC Laboratory of Molecular Biology, Cambridge.

In 1993, Frances Arnold became the first person to use a technique called ‘directed evolution’ to create new enzymes. Since then, she has refined the methods that are now routinely used to develop new catalysts.

The use of Frances Arnold’s enzymes include more environmentally friendly manufacturing of chemical substances and the production of renewable fuels.

George Smith received the award for developing a method known as phage display. This is where a bacteriophage - a virus that infects bacteria can be used to evolve new proteins. Sir Gregory Winter then used this method for the directed evolution of antibodies, with the aim of producing new pharmaceuticals.

The first pharmaceutical based on this method, adalimumab, was approved in 2002 and is used to treat rheumatoid arthritis, psoriasis and inflammatory bowel diseases. Phage display has since produced pharmaceuticals that can neutralise toxins, counteract autoimmune diseases and cure metastatic cancer.

Professor Dame Carol Robinson, Royal Society of Chemistry president, said: “Today’s Nobel Prize in chemistry highlights the tremendous role of chemistry in contributing to many areas of our lives including pharmaceuticals, detergents, green catalysis and biofuels. It is a great advert for chemistry to have impact in so many areas.

“Directed evolution of enzymes and antibody technology are subjects that I have followed with keen interest; both are now transforming medicine. It would have been hard to predict the outcome of this research at the start – this speaks to the need for basic research.

“I am delighted to see these areas of chemistry recognised and congratulate all three Nobel Laureates.”

Illustration: Niklas Elmehed. Copyright: Nobel Media AB 2018

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Vets to run marathon for World Animal Protection

News Story 1
 Two recently graduated veterinary surgeons will be running the London Marathon in April to raise money for the charity World Animal Protection.

Alex Bartlett and Maeve O'Neill plan to run the race together if they are given the same start times.

Dr O'Neill said: "You're always limited in what you can do to help animals, so it is nice to raise money for a charity that helps animals around the world."

Dr Bartlett added: "I have never run a marathon before and am excited to run my first one for such a good cause!"

Both Dr Bartlett and Dr O'Neill have fundraising pages online. 

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News Shorts
BSAVA releases new Guide to Procedures

The British Small Animal Veterinary Association (BSAVA) has published a new edition of its Guide to Procedures for Small Animal Practice.

It has added four new procedures; cystostomy tube placement, endotracheal intubation, point-of-care ultrasound and wet-to-dry dressings.

BSAVA says that it is an essential step-by-step guide to diagnostic and therapeutic procedures performed in practice. The textbook includes new images and illustrations, as well as high-definition videos for use prior to procedures.

Nick Bexfield and Julia Riggs, editors of the new edition, said: "We have built upon the success of the previous editions by responding to the feedback received from the BSAVA readership, and hope this new guide helps to further increase the confidence and accuracy with which these procedures are performed."

Print copies are available in the BSAVA store, with a digital version in the BSAVA library.