Cookie use on MRCVSonline
We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive all cookies.
If you would like to forward this story on to a friend, simply fill in the form below and click send.

Your friend's email:
Your email:
Your name:
 
 
Send Cancel

Nobel Prize awarded for enzyme research
Frances H. Arnold, George P. Smith and Sir Gregory Winter, 2018 Nobel Laureates in Chemistry.

Three scientists share 2018 Nobel Prize in Chemistry

The Nobel Prize in Chemistry 2018 has been awarded to three scientists for their research into enzymes.

Frances H. Arnold from the California Institute of Technology will share the award with George P. Smith, University of Missouri, and Sir Gregory P Winter from the MRC Laboratory of Molecular Biology, Cambridge.

In 1993, Frances Arnold became the first person to use a technique called ‘directed evolution’ to create new enzymes. Since then, she has refined the methods that are now routinely used to develop new catalysts.

The use of Frances Arnold’s enzymes include more environmentally friendly manufacturing of chemical substances and the production of renewable fuels.

George Smith received the award for developing a method known as phage display. This is where a bacteriophage - a virus that infects bacteria can be used to evolve new proteins. Sir Gregory Winter then used this method for the directed evolution of antibodies, with the aim of producing new pharmaceuticals.

The first pharmaceutical based on this method, adalimumab, was approved in 2002 and is used to treat rheumatoid arthritis, psoriasis and inflammatory bowel diseases. Phage display has since produced pharmaceuticals that can neutralise toxins, counteract autoimmune diseases and cure metastatic cancer.

Professor Dame Carol Robinson, Royal Society of Chemistry president, said: “Today’s Nobel Prize in chemistry highlights the tremendous role of chemistry in contributing to many areas of our lives including pharmaceuticals, detergents, green catalysis and biofuels. It is a great advert for chemistry to have impact in so many areas.

“Directed evolution of enzymes and antibody technology are subjects that I have followed with keen interest; both are now transforming medicine. It would have been hard to predict the outcome of this research at the start – this speaks to the need for basic research.

“I am delighted to see these areas of chemistry recognised and congratulate all three Nobel Laureates.”

Illustration: Niklas Elmehed. Copyright: Nobel Media AB 2018

Become a member or log in to add this story to your CPD history

Wildlife presenter to deliver keynote speech at BVA Congress

News Story 1
 The BVA has confirmed wildlife presenter Mike Dilger will deliver the keynote speech at this yearís congress. Mike is known as ĎBritainís most diseased maní, having contracted a number of exotic diseases on his travels, including malaria, bilharzia and leishmaniasis. His talk, ĎMy diseases and other animalsí, promises to be an amusing and inspiring lecture on his travels in the tropics and his thoughts on how the mass media is influencing human engagement with wildlife and nature. The lecture will take place at 1pm on 16 November, in the BVA Congress Theatre at Londonís ExCeL. 

Click here for more...
News Shorts
Vet school runs event for aspiring vets and nurses

Bristol Veterinary School is hosting an event for aspiring vets and vet nurses, to allow them to experience life as a student and find out what itís like to work in veterinary medicine. The one-day event, called VetQuest, will be held at the Langford Campus and includes a tour, talks on admissions and work experience, and the chance to take part in practical sessions. Taking place on Saturday 27 October, the event is primarily aimed at 11-12 year olds and costs £50, including lunch. There are a limited number of subsidised tickets for £10. To book, visit VetQuest 2018