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Discovery offers hope for anti-cancer therapy
Immunoglobulin E (IgE) antibodies are created when the immune system overreacts to an allergen.

Immunoglobulin E antibodies could fight cancer in humans and dogs

Antibodies that are produced in response to allergens could offer hope for a new anti-cancer therapy in dogs and humans, scientists have said.

Immunoglobulin E (IgE) antibodies are created when the immune system overreacts to an allergen, such as pollen. However, their original purpose is to repel harmful external substances.  

A team of international scientists have now developed a ‘canine IgE’ that targets the EGFR growth factor in cancerous tumours. In-vitro studies found that, in more than 60 per cent of cases, the tumour was destroyed by IgE antibodies.

IgE antibodies build a ‘bridge’ between EGFR on cancer cells and inflammatory cells, which releases tumour necrosis factors.

The study, published in the Journal of Allergy and Clinical Immunology, offers hope for humans too, as canine and human EGFR are a 92 per cent match.

Lead author Erika Jensen-Jarolim said: "We can therefore hope that we have made an important contribution towards developing a new form of immunotherapy against cancerous tumours.

"A subsequent clinical trial will be conducted in canine patients to validate the results in an international joint initiative before moving to human trials.”

Image © M. Bernkopf/Vetmeduni Vienna

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Petplan Veterinary Awards 2020 open for nominations

News Story 1
 Nominations are open for the 2020 Petplan Veterinary Awards, a prestigious event that pays recognition to some of the UKs most notable veterinary professionals.

We have been recognising the brilliant work of the UKs veterinary professionals through the Petplan Veterinary Awards for 21 years now and every year the standard of entries just gets higher, said James Barnes, head of sales and partnerships at Petplan.

To nominate a colleague for the awards visit petplanvet.co.uk/vetawards, before nominations close on 16th January 2020. Winners will be announced at the awards ceremony on 2 April 2020 in Birmingham. 

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News Shorts
BEVA survey seeks views about antibiotic use in horses

Equine vets are being invited to participate in a BEVA survey that aims to find out more about antimicrobial resistance in equine veterinary practice.

Designed by researchers at the University of Liverpool and incoming BEVA president Tim Mair, the survey aims to fill gaps in knowledge about how antimicrobials are being used in equine practice and the landscape of resistant infections encountered in equine practice.

Researchers hope the results will lead to a greater understanding of the role of antimicrobial treatment and antimicrobial resistance in horses and protect antibiotics for the future of equine and human health.