Cookie use on MRCVSonline
We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive all cookies.
If you would like to forward this story on to a friend, simply fill in the form below and click send.

Your friend's email:
Your email:
Your name:
 
 
Send Cancel

Researchers develop single vaccine for avian influenza and duck enteritis
Duck enteritis virus infects geese, swans and ducks, leading to loss of life in almost 100 per cent of cases.

CRISPR/Cas9 method applied to duck enteritis virus for the first time

Researchers at The Pirbright Institute have used gene editing technology to create a single vaccine for avian influenza and duck enteritis virus (DEV).

Writing in the journal Viruses, the researchers explain how they used a method of CRISPR/Cas9 gene editing to insert protective avian influenza virus genes into DEV. This method allows higher rates of gene insertion and makes the process more efficient.

DEV infects geese, swans and ducks, leading to loss of life in almost 100 per cent of cases. To reduce the impact of DEV, vaccines are used widely and have recently been employed for delivering components of other viruses such as avian influenza.

In SouthEast Asia, domestic duck populations also play a key role in maintaining the reservoir of severe bird flu strains and allow the infection to ‘spillover into chickens’. This makes them important targets for vaccination campaigns.

Like human flu, vaccination against avian flu is complicated by the hundreds of potential strains, with seasonal variations deciding which vaccine should be used. The gene editing technique used by The Pirbright Institute allows for the rapid development of vaccines that can protect against DEV whilst keeping up with the changing circulating flu strains.

“This is the first time this CRISPR/Cas9 method has been applied to duck enteritis virus and is an exciting step forward in the rapid development of bird flu vaccines,” said professor Munir Iqbal. “Vaccines that protect ducks against DEV as well as severe forms of avian flu will reduce production losses for duck farmers, safeguard other poultry species against flu infection and lower the risk of transmission to humans.”

Due to its large genome size, DEV is being increasingly to used to deliver protective genes to birds. The method’s design allows its application to different genres and viruses, opening up the possibility that other diseases can be tackled using this system.

The vaccine is now ready for registration and researchers at Pirbright are now seeking collaborations with pharmaceutical companies to commercialise the vaccine.

Become a member or log in to add this story to your CPD history

Amur leopard cubs caught on camera

News Story 1
 A pair of Amur leopards have been captured on camera for the first time since their birth. The Royal Zoological Society of Scotland announced the birth in July, but with human presence being kept to a minimum, it was not known how many cubs had been born.

Motion sensitive cameras have now revealed that two cubs emerged from the den - at least one of which may be released into the wild in Russia within the next two or three years. The Amur leopard habitat is not open to the public, to help ensure the cubs retain their wild instincts and behaviour. Image © RZSS 

Click here for more...
News Shorts
New canine and feline dentistry manual announced

A new canine and feline dentistry and oral surgery manual has been published by the BSAVA. Announcing the news on its website, the BSAVA said this latest edition contains new step-by-step operative techniques, together with full-colour illustrations and photographs.

‘This is a timely publication; veterinary dentistry is a field that continues to grow in importance for the general veterinary practitioner,’ the BSAVA said. ‘The manual has been fully revised and updated to include the most relevant, evidence-based techniques.’

The BSAVA Manual of Canine and Feline Dentistry and Oral Surgery, 4th edition is available to purchase from www.bsava.com/shop