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Snake venom protein could prevent blood clots
Researchers found that a protein derived from the venom of the tropidolaemus wagleri snake reduced the formation of blood clots in mice.

Discovery could lead to safer treatment for blood clots

A protein found in snake venom could lead to a safer treatment for blood clots, new research has found.

According to Medical News Today, a protein derived from the venom of the tropidolaemus wagleri snake has reduced the formation of blood clots in mice, without excessive bleeding.

The research was carried out by National Taiwan University in Taipei and published in the journal Arteriosclerosis, Thrombosis, and Vascular Biology.

Current methods for reducing the formation of blood clots - such as aspirin and clopidogrel - work by preventing platelets from clumping together. Doctors prescribe these antiplatelet medications to prevent heart attack, stroke and heart disease, but a major side effect is bleeding after an injury.

It is hoped that this new discovery could pave the way to a new antiplatelet drug that is equally effective, but not cause excessive bleeding.

Trowaglerix

In previous studies, researchers found that that trowaglerx - a protein found in the venom of tropidolaemus wagleri - interacts with glycoprotein VI (GPVI) - a protein that resides on the surface of platelets - to form blood clots.

In this new study, Dr Jane Tseng and her colleagues assessed the structure of this protein and were able to create a drug that blocks GPVI activity.

When they tested the drug on mice, the mice experienced slower blood clot formation. They also didn’t bleed any longer than mice that hadn’t been treated with the drug.

Dr Tseng believes the findings suggest that trowaglerix might offer a safer, effective strategy to prevent blood clots. But she stresses that more research is needed to ascertain the safety and efficacy of the drug in humans.

"In general, this type of molecule design does not last long in the body, so techniques like formulation or delivery system are likely needed to extend the exposure time in the human body," she told Medical News Today.

“The design must also be optimised to ensure that the molecule only interacts with GPVI and not other proteins which can cause unintended reactions."

Image (C) gbohne.

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Vets to run marathon for World Animal Protection

News Story 1
 Two recently graduated veterinary surgeons will be running the London Marathon in April to raise money for the charity World Animal Protection.

Alex Bartlett and Maeve O'Neill plan to run the race together if they are given the same start times.

Dr O'Neill said: "You're always limited in what you can do to help animals, so it is nice to raise money for a charity that helps animals around the world."

Dr Bartlett added: "I have never run a marathon before and am excited to run my first one for such a good cause!"

Both Dr Bartlett and Dr O'Neill have fundraising pages online. 

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News Shorts
BSAVA releases new Guide to Procedures

The British Small Animal Veterinary Association (BSAVA) has published a new edition of its Guide to Procedures for Small Animal Practice.

It has added four new procedures; cystostomy tube placement, endotracheal intubation, point-of-care ultrasound and wet-to-dry dressings.

BSAVA says that it is an essential step-by-step guide to diagnostic and therapeutic procedures performed in practice. The textbook includes new images and illustrations, as well as high-definition videos for use prior to procedures.

Nick Bexfield and Julia Riggs, editors of the new edition, said: "We have built upon the success of the previous editions by responding to the feedback received from the BSAVA readership, and hope this new guide helps to further increase the confidence and accuracy with which these procedures are performed."

Print copies are available in the BSAVA store, with a digital version in the BSAVA library.