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Novel vaccine protects against RSV
calf
The vaccine was used to immunise five calves aged three-to-six weeks, via two injections four weeks apart. (stock photo)
Success with cattle offers hope for human vaccine
 
A novel vaccine has shown success in protecting cattle from respiratory syncytial virus (RSV) infection, and could offer hope for a human vaccine, researchers say.

RSV causes the majority of respiratory disease in cattle and is responsible for substantial economic loss. In humans, it causes serious bronchiolitis and pneumonia in young children, the elderly and people with compromised immune systems. There are estimated to be more than 250,000 human deaths a year as a result of RSV infection.

Currently there is no licensed vaccine for humans and cattle vaccines have noted issues with safety and effectiveness.

Research on the novel vaccine was conducted by a team of experts from the National Institute of Allergy and Infectious Diseases (NIAID) in the US, the Pirbright Institute in the UK and the Institute for Research in Biomedicine in Switzerland.

The vaccine was used to immunise five calves aged three-to-six weeks, via two injections four weeks apart. It contains a single, structurally engineered RSV protein, which is a stabilised version of the RSV fusion (F) glycoprotein it its initial conformation, pre-F. Other vaccines have used the same protein in its final conformation, post-F, but scientists say the immune response is much lower.

A second group of five calves were injected with a post-F protein, while the third group received two placebo injections of saline.

Four weeks later, calves in all three groups were infected with RSV. Of those injected with pre-F, four out of five were protected from RSV viral replication in the upper and lower respiratory tract and calves had high levels of neutralising antibodies - more than 100 fold higher than those given the post-F vaccine. However, RSV was detected in all calves given the post-F vaccine or the placebo.

Researchers say their findings, which were published in npj Vaccines, support further work on pre-F vaccines to protect humans and cattle from RSV. NIAID recently started testing a similar vaccine in a phase one human trial.

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New DNA testing scheme for the Russian black terrier

News Story 1
 A new DNA testing scheme for juvenile laryngeal paralysis and polyneuropathy (JLPP) in the Russian black terrier has been approved by The Kennel Club.

JLPP is a genetic disease that affects the nerves. In affected dogs, it starts with the nerve that supplies the muscles of the larynx leading to muscle weakness and laryngeal paralysis.

To find out which laboratories the Kennel Club is able to record results from, and which labs will send results direct to the Kennel Club, visit thekennelclub.org.uk.

 

News Shorts
Feline art marks 90 years of Cats Protection

Sussex-based charity Cats Protection is hosting a prestigious art exhibition to mark its 90th anniversary.

More than 200 paintings provided by members of the Society of Feline Artists will go on show at the charity's National Cat Centre in Chelwood Gate (28 April - 7 May).

"Art enthusiasts, students and cat lovers alike will all enjoy the exhibition, and we hope it will also inspire some of our younger visitors to get sketching," said Cats Protection's director of fundraising, Lewis Coghlin.