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Scientists discover how ticks protect themselves from Lyme disease
Ticks have an entirely different immune system from other insects.
Finding could pave way to new interventions

How ticks can survive whilst harbouring bacteria, viruses and parasites has been unravelled by scientists at the University of Maryland.

The research, published in the journal Nature Communications, reveals that ticks have an entirely different immune system from other insects.

For a long time, scientists believed that the tick immune system worked in a similar way to that of mosquitoes and flies. But the researchers found that, in evolutionary terms, ticks are as far removed from insects, as humans are from fish.

"Although the two bugs are seemingly alike, it turns out that the immune system of ticks is quite distinct from insects. Our discovery clarifies the ins-and-outs of how the tick immune system fights bacteria," said senior author Dr Joao Pedra.

The reasearchers first observed that ticks do not possess crucial genes for a proper immune response. This led them to discover a new pathway that recognises three distinct bacteria: the Lyme disease pathogen, Borrelia burgdorferi, and two that cause rickettsial illnesses, Anaplasma phagocytophilum and Anaplasma marginale.

Once the team had identified the components of a tick’s immune system, they proceeded to block the immune response with a molecular technique known as RNA interference. They also over-activated the ticks’ immune system to get rid of bacteria even more efficiently.

According to Science Daily, the team believes that discovery could have exciting implications: by manipulating the tick’s immune system, it might be possible to make ticks less vulnerable to infection. If ticks do not pick up these bacteria in the wild, then they will not be able to pass them on to humans.

“This basic science discovery is fascinating, and may pave the ground for new translational approaches that reduce the negative impact of tick-borne diseases in people,” said Dr Pedra.

More research is now underway to further understand the tick immune response. 

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Blue Dog Programme wins WSAVA One Health award

News Story 1
 An educational initiative to help children interact safely with dogs has been awarded the WSAVA’s 2017 Global One Health Award.

The Blue Dog Programme offers an array of educational resources for children, parents and school teachers, including an engaging website, fact sheets, DVD and an accompany book for parents.

The award will be accepted by Professor Tiny de Keuster, a European veterinary specialist in behavioural medicine and founder of the programme, during WSAVA World Congress 2017.  

News Shorts
VMD stakeholder workshops to discuss Brexit implications

The Veterinary Medicines Directorate (VMD) has announced that it is to hold stakeholder group workshops to discuss the implications of EU exit.

The workshops will be held during Autumn 2017 and will discuss topics such as the prescribing cascade, pharmacovigilance and inspection of non-UK based manufacturers.

To register your interest, send an email to events@vmd.defra.gsi.gov.uk, including any topics, in order of preference, that you would like to be discussed.