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Study reveals how Lyme disease spreads through the body
Lyme disease bacteria
Lyme disease bacteria (Borrelia burgdorferi) spreads through the body by clinging to the lining of blood vessels.

Cell-imaging approach offers new insights

Research by the University of Toronto has revealed how Lyme disease bacteria spreads through the body.

Published in the journal Cell Reports, the study found that a special adhesion protein called BBK32 helps Lyme disease bacteria (Borrelia burgdorferi) cling onto and move along the inside lining of blood vessels.  

"It's likely that this property helps the bacteria get to sites where they might be able to persist longer, and this property might therefore make it harder to treat infections caused by these bacteria," explains first author Rhodaba Ebady.

In the study, the team developed a live-imaging-cell based system that provides both molecular and biomechanical insights into how bacteria travels throughout the body.

Using genetically modified strains of Borrelia burgdorferi, the team watched through a microscope as the bacteria - marked with fluorescent green protein - moved across cells in real time.

Their findings suggest that drugs targeting BBK32 could help to prevent or slow down the spread of Lyme disease bacteria to joints, the heart and nervous system.

This would eliminate or reduce the severity of symptoms like heart inflammation, arthritis, facial paralysis and nerve pain, the researchers say.

Furthermore, because BBK32-like proteins are produced by pathogens like Staphylococcus aureus and Streptococcus pyogenes, the researchers believe their findings may also be relevant to other serious conditions, like pneumonia and inflammation affecting the heart.

Looking ahead, the team hope to identify endothelial receptors that BBK32 interact with, assess the biomechanical role of bacterial flagella in vascular interactions, and try to determine how bacteria target specific endothelia associated with different tissues.

More broadly, the team hope their cell-imaging approach could be used to study how other pathogens spread throughout the body.

Image (C) Jamice Haney Carr, Claudia Molins, USCDCP 

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RCVS carries out annual VN CPD audit

News Story 1
 The RCVS is carrying out its annual veterinary nurse CPD audit and has sent out requests for the CPD records of more than 1,100 nurses this week.

Under the RCVS Code of Professional Conduct, nurses are required to carry out at least 45 hours of CPD over a rolling three-year period. This year, 1,130 nurses have been asked to share their records from 2016-2018 to show that they have complied with the requirements.

Earlier this year, the VN Council decided to expedite the referral process for nurses who have not complied with the CPD requirement for three or more years. In such cases nurses will have their records sent to the CPD Referral Group. 

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Kew Gardens seeking vets for Ethnoveterinary Medicine Project

A new project at the Royal Botanical Gardens, Kew, is seeking the help of vets to find out how plants were traditionally used to treat animals.

The Ethnoveterinary Medicine Project is aiming to record the remaining knowledge from across the British Isles, before it disappears.

Visit the Kew Gardens website for more information or email ethnovet@kew.org to share data.