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Scientists repair liver using stem cells
mouse
Liver stem cells were transplanted into mice with liver failure. (stock photo)
Findings bring us "a step closer" to new therapies
 
For the first time, scientists have managed to repair a severely damaged liver using stem cells grown in the laboratory.

It is hoped their findings will lay the foundations for cell-based therapies in the future, which could offer those with liver failure an alternative to organ transplants.

Scientists from the University of Edinburgh transplanted liver stem cells into mice with liver failure. Over several months, they saw major parts of the liver being regrown from these cells, improving its structure and function.

It is the first time researchers have been able to repair the liver to this extent. If the same effect can be demonstrated with human cells this could be a useful treatment for liver failure.

"Revealing the therapeutic potential of these liver stem cells brings us a step closer to developing stem cell based treatments for patients with liver disease," said Professor Stuart Forbes, from the university's Medical Research Council Centre for Regenerative Medicine.

"It will be some time before we can turn this into reality as we will first need to test our approach using human cells. This is much needed as liver disease is a very common cause of death and disability for patients in the UK and the rest of the world.’"

Long-term, the team are hoping to find a way of using medicines to stimulate the patient's own stem cells to repair the damage.

Although the liver has a great capacity to repair itself, conditions such as cirrhosis and liver failure make this impossible.

Hepatocytes within the liver make proteins and break down toxins. They have been used for transplantation before but their use is limited by the fact that they don't grow well under lab conditions.

This can be overcome with liver stem cells as they can be grown in these conditions and can change into hepatocytes and other types of liver cell.

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Vets to run marathon for World Animal Protection

News Story 1
 Two recently graduated veterinary surgeons will be running the London Marathon in April to raise money for the charity World Animal Protection.

Alex Bartlett and Maeve O'Neill plan to run the race together if they are given the same start times.

Dr O'Neill said: "You're always limited in what you can do to help animals, so it is nice to raise money for a charity that helps animals around the world."

Dr Bartlett added: "I have never run a marathon before and am excited to run my first one for such a good cause!"

Both Dr Bartlett and Dr O'Neill have fundraising pages online. 

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News Shorts
BSAVA releases new Guide to Procedures

The British Small Animal Veterinary Association (BSAVA) has published a new edition of its Guide to Procedures for Small Animal Practice.

It has added four new procedures; cystostomy tube placement, endotracheal intubation, point-of-care ultrasound and wet-to-dry dressings.

BSAVA says that it is an essential step-by-step guide to diagnostic and therapeutic procedures performed in practice. The textbook includes new images and illustrations, as well as high-definition videos for use prior to procedures.

Nick Bexfield and Julia Riggs, editors of the new edition, said: "We have built upon the success of the previous editions by responding to the feedback received from the BSAVA readership, and hope this new guide helps to further increase the confidence and accuracy with which these procedures are performed."

Print copies are available in the BSAVA store, with a digital version in the BSAVA library.