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Virtual fish could reduce animal testing
Image rainbow trout
Previously, the university has managed to form a ball of liver cells from rainbow trout.

Plymouth scientists hope to reduce testing on live fish

A virtual fish is being developed at Plymouth University with hopes of reducing the need to test on live animals.

Scientists believe the virtual fish could be useful for studying the risks of man-made chemicals in the environment. Leading the project, Professor Awadhesh Jha says traditionally, live animals are used for this.

"For ethical and legal reasons, there has been much emphasis on the use of cells, tissues and organs grown outside the body," he explains.

Plymouth scientists will look at how well the virtual fish compares to testing on a live animal. It is thought just a few live fish could generate enough cells for the amount of testing needed.

The project has been awarded a grant of £600,000 from the Biotechnology and Biological Sciences Research Council, the Natural Environmental Research Council and pharmaceutical company AstraZeneca.

Previously, the university has managed to form a ball of liver cells from rainbow trout. Plymouth researchers say this ball gives a more accurate picture of how an animal's body would respond to a chemical in the environment, than cells grown in a laboratory.

Scientists will now work on developing the technique using cells from the gut and gills of fish. The model was developed by PhD student Matthew Baron, as part of a project led by Prof Jha.

"We have already demonstrated that using fish liver cells maintains basic biochemical functions, can metabolise environmentally relevant contaminants and therefore has the potential to replace whole animal tests," said Prof Jha.

"Since billions of cells from several different organs can be harvested from a single fish, it means that far fewer fish will be used in research, and those that are will not be used directly in experiments."

UK Government figures show nearly 59,000 live fish were used for research testing environmental pollutants in 2011. Strict government rules mean the number of products that will need testing globally could translate into millions of live animals in coming years.

The three-year project began this month and research will be conducted at Plymouth University in collaboration with AstraZeneca.

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Vets to run marathon for World Animal Protection

News Story 1
 Two recently graduated veterinary surgeons will be running the London Marathon in April to raise money for the charity World Animal Protection.

Alex Bartlett and Maeve O'Neill plan to run the race together if they are given the same start times.

Dr O'Neill said: "You're always limited in what you can do to help animals, so it is nice to raise money for a charity that helps animals around the world."

Dr Bartlett added: "I have never run a marathon before and am excited to run my first one for such a good cause!"

Both Dr Bartlett and Dr O'Neill have fundraising pages online. 

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News Shorts
BSAVA releases new Guide to Procedures

The British Small Animal Veterinary Association (BSAVA) has published a new edition of its Guide to Procedures for Small Animal Practice.

It has added four new procedures; cystostomy tube placement, endotracheal intubation, point-of-care ultrasound and wet-to-dry dressings.

BSAVA says that it is an essential step-by-step guide to diagnostic and therapeutic procedures performed in practice. The textbook includes new images and illustrations, as well as high-definition videos for use prior to procedures.

Nick Bexfield and Julia Riggs, editors of the new edition, said: "We have built upon the success of the previous editions by responding to the feedback received from the BSAVA readership, and hope this new guide helps to further increase the confidence and accuracy with which these procedures are performed."

Print copies are available in the BSAVA store, with a digital version in the BSAVA library.